NPIT - A NEW REAGENT FOR QUANTITATIVELY MONITORING REACTIONS OF AMINES IN COMBINATORIAL SYNTHESIS

被引：33

作者：

CHU, SS ^{[1
]}

REICH, SH ^{[1
]}

机构：

[1] AGOURON PHARMACEUT INC,SAN DIEGO,CA 92120

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/0960-894X(95)00164-O

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new reagent, nitro phenylisothiocyanate-O-trityl (NPIT), has been developed for the quantitative or qualitative analysis of amines on solid support. NPIT can be used to efficiently monitor reactions involving less reactive amines during combinatorial synthesis of compound library mixtures.

引用

页码：1053 / 1058

页数：6