A SODIUM-POTASSIUM SWITCH IN THE FORMATION OF 4-STRANDED G4-DNA

被引：756

作者：

SEN, D

GILBERT, W

机构：

[1] Department of Cellular and Developmental Biology, Harvard University, Cambridge

来源：

NATURE | 1990年 / 344卷 / 6265期

关键词：

D O I：

10.1038/344410a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and else-where can associate to form stable parallel four-stranded structures termed G4-DNA by a process that is anomalously dependent on the particular alkali metal cation that is present. The anomaly, which is not found in the formation of G4-DNA by oligonucleotides containing short, single runs of three or more guanines, is caused by potassium cations excessively stabilizing fold-back intermedi-ate structures, or pathway by-products. © 1990 Nature Publishing Group.

引用

页码：410 / 414

页数：5

共 27 条

[21] FORMATION OF PARALLEL 4-STRANDED COMPLEXES BY GUANINE-RICH MOTIFS IN DNA AND ITS IMPLICATIONS FOR MEIOSIS [J].