AN ULTRASTRUCTURAL AND MORPHOMETRIC STUDY OF THE EFFECT OF REMOVAL OF RETINAL INPUT ON THE DEVELOPMENT OF THE DORSAL LATERAL GENICULATE-NUCLEUS

被引：6

作者：

BRUNSOBECHTOLD, JK

VINSANT, SL

机构：

[1] Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina

来源：

JOURNAL OF COMPARATIVE NEUROLOGY | 1990年 / 301卷 / 04期

关键词：

afferents; degeneration; lamination; synaptogenesis; tree shrew;

D O I：

10.1002/cne.903010408

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In normal development, cell layers in the dorsal lateral geniculate nucleus (dLGN) segregate from a relatively homogeneous cell group. If all retinal input is removed prior to this segregation, the layers fail to form. In the present study, we used ultrastructural and morphometric analyses to study dLGN development in the tree shrew following neonatal removal of retinal input. The goal of the present study was to determine whether there are differences between normal animals and enucleates in the development of dLGN cells and their interrelationships with each other and/or with the surrounding glia, which might explain the failure of cellular lamination in enucleated animals. The results indicate that although the development in enucleated animals may take place somewhat more slowly, by P90 cell size and density are not significantly different from normal. These results, coupled with the observation that the dLGN in enucleates is smaller than in normals, suggest that the removal of retinal input results in dLGN cell loss. At both the light and electron microscopic level, cells in the developing normal dLGN are arranged in bands of immediately adjacent cells. In enucleates, dLGN cells are less frequently in immediate contact and are arranged in small groups or clumps which may be separated by degenerating cells. The present data suggest that the presence of retinal input may be necessary to allow dLGN cells to maintain the intercellular relationships necessary for laminar segregation to take place. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：585 / 603

页数：19

共 71 条

[11]

Chalupa L.M., Williams R.W., Organization of the cat's lateral geniculate nucleus following interruption of prenatal binocular competition, Human Neurobiology, 3, pp. 103-108, (1984)

[12]

Clarke Peter G.H., Neuronal death during development in the isthmo‐optic nucleus of the chick: Sustaining role of afferents from the tectum, J. Comp. Neurol., 234, pp. 365-379, (1985)

[13]

Cowan W.M., Anterograde and retrograde transneuronal degeneration in the central and peripheral nervous system, Contemporary Research Methods in Neuroanatomy, pp. 217-249, (1970)

[14]

Cullen M.J., Kaiserman-Abramof I.R., Cytological organization of the dorsal lateral geniculate nuclei in mutant anophthalmic and postnatally enucleated mice, J. Neurocytol., 5, pp. 407-424, (1976)

[15]

Cunningham T.J., Naturally occurring neuron death and its regulation by developing neural pathways, Int. Rev. Cytol., 74, pp. 163-186, (1982)

[16]

Cusick C.G., Lund R.D., Modification of visual callosal projections in rats, J. Comp. Neurol., 21, pp. 385-398, (1982)

[17]

Finlay B.L., Sengelaub D.R., Berian C.A., Control of cell number in the developing visual system: I. Effects of monocular enucleation, Dev. Brain Res., 28, pp. 1-10, (1986)

[18]

Fitzpatrick D., Conley M., Luppino G., Matelli M., Diamond I.T., Cholinergic projections from the midbrain reticular formation and the parabigerminal nucleus to the lateral geniculate nucleus in the tree shrew, J. Comp. Neurol., 272, pp. 43-67, (1988)

[19]

Friedlander M.J., Stanford L.R., Sherman S.M., Effects of monocular deprivation on the structure‐function relationship of the individual neurons in the cat's lateral geniculate nucleus, J. Neurosci., 2, pp. 321-330, (1982)

[20]

Fukuda Y., Hsiao C.-F., Bilateral changes in some size of geniculate relay cells and corticogeniculate cells after neonatal monocular enucleation in rat, Brain Res., 301, pp. 13-24, (1984)

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