A NOVEL, GENERAL-METHOD FOR THE PREPARATION OF ALPHA,ALPHA-DIFLUORO FUNCTIONALIZED PHOSPHONATES

被引：45

作者：

YANG, ZY ^{[1
]}

BURTON, DJ ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 08期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)74476-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition reaction of diethyl iododifluoromethylphosphonate to alkenes catalyzed by palladium in the absence of solvent gives the corresponding adducts in good yields at room temperature. A variety of functional groups in the alkenes, including alkyl, trimethylsilyl, hydroxy, epoxy, ketone and ester, are tolerated under the reaction conditions. The reduction of the adducts with nickel chloride and zinc in moist THF provides the title compounds.

引用

页码：1019 / 1022

页数：4

共 23 条

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