A NOVEL CHEMOENZYMATIC ENANTIOSPECIFIC SYNTHESIS OF (S)-CORIOLIC ACID MEDIATED VIA IMMOBILIZED ALCOHOL-DEHYDROGENASE OF BAKER YEAST

被引：8

作者：

BHALERAO, UT

DASARADHI, L

MURALIKRISHNA, C

FADNAVIS, NW

机构：

[1] Indian Institute of Chemical Technology, Hyderabad

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)77613-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S)-(E)-(+)-1-Bro mo-1-octene-3-ol was prepared in 85% yield and high optical purity (e.e. 97.4%) via a stereospecific reduction of corresponding bromo vinyl ketone using alcohol dehydrogenase from baker's yeast (EC 1.1.1.1) and NAD(P)H immobilized on Nucleosil 120-5 C18, and converted to 13(S)-hydroxy-9Z,11E-octadecadienoic (coriolic) acid.

引用

页码：2359 / 2360

页数：2