ASYMMETRIC REDUCTION OF A CARBON-NITROGEN DOUBLE-BOND - ENANTIOSELECTIVE SYNTHESIS OF 4,5-DIHYDRO-3H-2,3-BENZODIAZEPINES

被引：23

作者：

LING, I

PODANYI, B

HAMORI, T

SOLYOM, S

机构：

[1] Institute for Drug Research Ltd., H-1325 Budapest

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 11期

关键词：

D O I：

10.1039/p19950001423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly specific enantioselective reduction, elaborated for the reduction of the 3,4-carbon-nitrogen double bond of 4-methyl-7,8-methylenedioxy-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine 4 made possible the synthesis of the enantiomers of the potent non-competitive AMPA/kainate antagonists 2a, b. NMR Investigations of the reducing complex show that there is no formation of an 1,3,2-oxazaborolidine ring as may have been presumed on the basis of literature data.

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页码：1423 / 1427

页数：5

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