SOME RECENT DEVELOPMENTS IN THE USE OF ENZYME CATALYZED-REACTIONS IN ORGANIC-SYNTHESIS

被引：28

作者：

ROBERTS, SM

TURNER, NJ

机构：

[1] Department of Chemistry, University of Exeter, Exeter, Devon

来源：

JOURNAL OF BIOTECHNOLOGY | 1992年 / 22卷 / 03期

关键词：

ENZYME; BIOTRANSFORMATION; WHOLE-CELL; STEREOSELECTIVE SYNTHESIS;

D O I：

10.1016/0168-1656(92)90143-W

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The following processes are discussed in this article: enzyme-catalysed hydrolyses of carboxylic acid esters and amides, phosphate esters, nitriles and epoxides; esterification and inter-esterification reactions catalysed by enzymes; reduction of ketones to secondary alcohols using whole-cell systems or isolated dehydrogenases; oxidation of alicyclic and aromatic substrates using mono-oxygenases and dioxygenases in bacteria and fungi including enzyme-catalysed Baeyer-Villiger oxidation; aldol reactions; formation of optically active cyanohydrins and enzyme-catalysed acyloin type reactions. The use of these biocatalytic methods for the stereo-controlled preparation of important target structures is reviewed and some of the future directions for the biotransformation area are discussed.

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页码：227 / 244

页数：18

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