A NOVEL SYNTHESIS OF THE C1-C17 FRAGMENT OF CARZINOPHILIN

被引：25

作者：

HASHIMOTO, M ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(00)78556-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was achieved by featuring i) condensation of the 2-methylthio-Delta(1)-pyrroline (C8-C13 moiety) with the Delta(2)-oxazolin-5-one (C6, C7, N16, and C17 moiety), ii) activation of the Delta(2)-oxazolin-5-one system toward nucleophilic reaction by introducing an allyoxycarbonyl group into the N9 position and subsequent ring opening with the 2-aminobutane (C1-N5 moiety), and iii) base-induced construction of the (E)-1-azabicyclo[3.1.0] hexane system from the 5-mesyloxymethyl-pyrrolidine as key steps.

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页码：9409 / 9412

页数：4

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