C/ATF, A MEMBER OF THE ACTIVATING TRANSCRIPTION FACTOR FAMILY OF DNA-BINDING PROTEINS, DIMERIZES WITH CAAT ENHANCER-BINDING PROTEINS AND DIRECTS THEIR BINDING TO CAMP RESPONSE ELEMENTS

被引:230
作者
VALLEJO, M
RON, D
MILLER, CP
HABENER, JF
机构
[1] Department of Cell Biology, New York University Medical Center, New York, NY 10016
关键词
D O I
10.1073/pnas.90.10.4679
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Members of the C/EBP family of basic-leucine zipper (bZip) transcription factors form heterodimers and bind to the CAAT box and other sequence-related enhancer motifs. Using a P-32-labeled protein probe consisting of the bZip domain of C/EBPbeta, we isolated a clone encoding C/EBP-related ATF (C/ATF), a bZip protein that heterodimerizes with C/EBP-like proteins but belongs to the CREB/ATF family. C/ATF homodimers do not bind to typical C/EBP DNA sites. Instead they bind to palindromic cAMP response elements such as that of the somatostatin gene. In addition, C/ATF-C/EBPbeta heterodimers bind to a subclass of asymmetric cAMP response elements exemplified by those in the phosphoenolpyruvate carboxykinase and proenkephalin genes. Transient transfection studies indicate that interactions between C/ATF and C/EBPbeta are the basis for a functional cross talk between these two families of transcription factors that may be important for the integration of hormonal and developmental stimuli that determine the expression of subsets of genes in specific cellular phenotypes.
引用
收藏
页码:4679 / 4683
页数:5
相关论文
共 25 条
[1]   CAAT ENHANCER BINDING-PROTEIN IS ABLE TO BIND TO ATF CRE ELEMENTS [J].
BAKKER, O ;
PARKER, MG .
NUCLEIC ACIDS RESEARCH, 1991, 19 (06) :1213-1217
[2]   MULTIPLE CIS-ACTING DNA REGULATORY ELEMENTS MEDIATE HEPATIC ANGIOTENSINOGEN GENE-EXPRESSION [J].
BRASIER, AR ;
TATE, JE ;
RON, D ;
HABENER, JF .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (06) :1022-1034
[3]   A FAMILY OF CONSTITUTIVE C/EBP-LIKE DNA-BINDING PROTEINS ATTENUATE THE IL-1-ALPHA INDUCED, NF-KAPPA-B MEDIATED TRANSACTIVATION OF THE ANGIOTENSINOGEN GENE ACUTE-PHASE RESPONSE ELEMENT [J].
BRASIER, AR ;
RON, D ;
TATE, JE ;
HABENER, JF .
EMBO JOURNAL, 1990, 9 (12) :3933-3944
[4]   REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS [J].
CAO, ZD ;
UMEK, RM ;
MCKNIGHT, SL .
GENES & DEVELOPMENT, 1991, 5 (09) :1538-1552
[5]   PROTEINS BOUND AT ADJACENT DNA ELEMENTS ACT SYNERGISTICALLY TO REGULATE HUMAN PROENKEPHALIN CAMP INDUCIBLE TRANSCRIPTION [J].
COMB, M ;
MERMOD, N ;
HYMAN, SE ;
PEARLBERG, J ;
ROSS, ME ;
GOODMAN, HM .
EMBO JOURNAL, 1988, 7 (12) :3793-3805
[6]  
Dayhoff MO, 1978, ATL PROTEIN SEQ STRU, V5, P345
[7]   CROSS-FAMILY DIMERIZATION OF TRANSCRIPTION FACTORS FOS JUN AND ATF CREB ALTERS DNA-BINDING SPECIFICITY [J].
HAI, T ;
CURRAN, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3720-3724
[8]   TRANSCRIPTION FACTOR ATF CDNA CLONES - AN EXTENSIVE FAMILY OF LEUCINE ZIPPER PROTEINS ABLE TO SELECTIVELY FORM DNA-BINDING HETERODIMERS [J].
HAI, TW ;
LIU, F ;
COUKOS, WJ ;
GREEN, MR .
GENES & DEVELOPMENT, 1989, 3 (12B) :2083-2090
[9]   CYCLIC-AMP - RESPONSIVE DNA-BINDING PROTEIN - STRUCTURE BASED ON A CLONED PLACENTAL CDNA [J].
HOEFFLER, JP ;
MEYER, TE ;
YUN, Y ;
JAMESON, JL ;
HABENER, JF .
SCIENCE, 1988, 242 (4884) :1430-1433
[10]   MOLECULAR-CLONING OF HUMAN CREB-2 - AN ATF/CREB TRANSCRIPTION FACTOR THAT CAN NEGATIVELY REGULATE TRANSCRIPTION FROM THE CAMP RESPONSE ELEMENT [J].
KARPINSKI, BA ;
MORLE, GD ;
HUGGENVIK, J ;
UHLER, MD ;
LEIDEN, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :4820-4824