PYRROLO[2,1-C][1,4]BENZODIAZEPINES - A MILD CONVERSION OF THIOLACTAM INTO AMIDINE

被引：37

作者：

FOLOPPE, MP ^{[1
]}

RAULT, S ^{[1
]}

ROBBA, M ^{[1
]}

机构：

[1] UFR SCI PHARMACEUT CAEN,CHIM THERAPEUT LAB,1 RUE VAUBENARD,F-14032 CAEN,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 20期

关键词：

PYRROLO[2,1-C][1,4]BENZODIAZEPINES; THIOLACTAM; MERCURIC CHLORIDE; AMIDINE;

D O I：

10.1016/S0040-4039(00)78862-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 2-hydroxy pyrrolo [2.1-c][1,4]benzodiazepines-5-one-11-thione or 5,11-dithiones with ammonia in presence of mercuric chloride affords new amidines in high yield.

引用

页码：2803 / 2804

页数：2

共 10 条

[1] CHOLECYSTOKININ ANTAGONISTS - SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-SUBSTITUTED 1,4-BENZODIAZEPIN-2-AMINES [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

FREIDINGER, RM ;

CHANG, RSL ;

LOTTI, VJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) :264-268

[2]

FOLOPPE MP, 1992, IN PRESS EUR J MED C

[3] PYRROLO[1,4]BENZODIAZEPINE ANTITUMOR ANTIBIOTICS - RELATIONSHIP OF DNA ALKYLATION AND SEQUENCE SPECIFICITY TO THE BIOLOGICAL-ACTIVITY OF NATURAL AND SYNTHETIC COMPOUNDS [J].

HURLEY, LH ;

RECK, T ;

THURSTON, DE ;

LANGLEY, DR ;

HOLDEN, KG ;

HERTZBERG, RP ;

HOOVER, JRE ;

GALLAGHER, G ;

FAUCETTE, LF ;

MONG, SM ;

JOHNSON, RK .

CHEMICAL RESEARCH IN TOXICOLOGY, 1988, 1 (05) :258-268

[4]

HURLEY LH, 1984, PHARM RES-DORDR, V2, P52

[5] REACTION OF PYRROLO[2,1-C][1,4]BENZODIAZEPINE-2,5,11-TRIONES WITH PHOSPHORUS OXYCHLORIDE [J].

KAMAL, A ;

THURSTON, DE .

TETRAHEDRON LETTERS, 1989, 30 (45) :6221-6222

[6] A NEW AND MILD METHOD FOR THE REDUCTION OF SECONDARY AMIDES TO CARBINOLAMINE ETHERS AND IMINES - A CONVERSION OF OXOTOMAYMYCIN TO TOMAYMYCIN [J].

KANEKO, T ;

WONG, H ;

DOYLE, TW .

TETRAHEDRON LETTERS, 1983, 24 (47) :5165-5168

[7]

KANEKO T, 1984, J ANTIBIOT, V37, P300, DOI 10.7164/antibiotics.37.300

[8] A CONVENIENT SYNTHESIS OF AZETIDINE-2-THIONES AND AZETIDIN-2-IMINES [J].

MARCHANDBRYNAERT, J ;

MOYAPORTUGUEZ, M ;

HUBER, I ;

GHOSEZ, L .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1983, (15) :818-819

[9]

REMERS WA, 1988, CHEM ANTITUMOR ANTIB, V2, P28

[10] SYNTHESIS AND STEREOCHEMISTRY OF CARBINOLAMINE-CONTAINING PYRROLO[1,4]BENZODIAZEPINES BY REDUCTIVE CYCLIZATION OF N-(2-NITROBENZOYL)PYRROLIDINE-2-CARBOXALDEHYDES [J].

THURSTON, DE ;

LANGLEY, DR .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (05) :705-712

← 1 →