LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN-E CONCENTRATIONS

被引：867

作者：

MARSH, DG

NEELY, JD

BREAZEALE, DR

GHOSH, B

FREIDHOFF, LR

EHRLICHKAUTZKY, E

SCHOU, C

KRISHNASWAMY, G

BEATY, TH

机构：

[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT EPIDEMIOL, BALTIMORE, MD 21205 USA

[2] ALLERGOL ALK LAB AS, DK-2970 HORSHOLM, DENMARK

来源：

SCIENCE | 1994年 / 264卷 / 5162期

关键词：

D O I：

10.1126/science.8178175

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.

引用

页码：1152 / 1156

页数：5

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[31] THE EPIDEMIOLOGY AND GENETICS OF ATOPIC ALLERGY [J].