PREPARATION AND FUNGITOXICITY OF 3,6-DICHLORO-8-QUINOLINOL AND 3,6-DIBROMO-8-QUINOLINOL

被引：18

作者：

GERSHON, H ^{[1
]}

CLARKE, DD ^{[1
]}

GERSHON, M ^{[1
]}

机构：

[1] NEW YORK BOT GARDEN,BRONX,NY 10458

来源：

MONATSHEFTE FUR CHEMIE | 1994年 / 125卷 / 6-7期

关键词：

3,6-DICHLORO-8-NITROQUINOLINE; 3,6-DIBROMO-8-NITROQUINOLINE; 8-AMINO-3,6-DICHLOROQUINOLINE; 8-AMINO-3,6-DIBROMOQUINOLINE; 3,6-DICHLORO-8-QUINOLINOL; 3,6-DIBROMO-8-QUINOLINOL; H-1 NMR SPECTRA;

D O I：

10.1007/BF01277632

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via a Skraup reaction. The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70% sulfuric acid at 220-degrees-C. The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, against Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date.

引用

页码：723 / 730

页数：8