REGIOSELECTIVE SULFATION OF DISACCHARIDES USING DIBUTYLSTANNYLENE ACETALS

被引：34

作者：

GUILBERT, B ^{[1
]}

DAVIS, NJ ^{[1
]}

FLITSCH, SL ^{[1
]}

机构：

[1] DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)78273-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective sulfation of partially protected disaccharides was achieved from their dibutylstannylene acetals by treatment with sulfur troxide/trimethylamine. Using this methodology 3'-sulfo-N-acetyllactosaminide 5, which is a substrate for fucosyltransferases and is the partial structure of 3'-sulfo-Lewis(X), can be synthesised in two steps from the N-acetylglucosaminide 3 without the need for hydroxyl group protection. Regioselective sulfation was also observed for partially protected maltosides 6 and 7.

引用

页码：6563 / 6566

页数：4

共 17 条

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