OXIDATIVE STRESS AS A MEDIATOR OF APOPTOSIS

被引：1997

作者：

BUTTKE, TM ^{[1
]}

SANDSTROM, PA ^{[1
]}

机构：

[1] CTR DIS CONTROL, RETROVIRUS DIS BRANCH, ATLANTA, GA 30333 USA

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 01期

关键词：

D O I：

10.1016/0167-5699(94)90018-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many agents which induce apoptosis are either oxidants or stimulators of cellular oxidative metabolism. Conversely, many inhibitors of apoptosis have antioxidant activities or enhance cellular antioxidant defenses. Mammalian cells exist in a state of oxidative siege in which survival requires an appropriate balance of oxidants and antioxidants. Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.

引用

页码：7 / 10

页数：4

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