ADIPOSE-TISSUE FATTY-ACIDS IN SCOTTISH MEN AND WOMEN - RESULTS FROM THE SCOTTISH HEART HEALTH STUDY

被引:46
作者
TAVENDALE, R [1 ]
LEE, AJ [1 ]
SMITH, WCS [1 ]
TUNSTALLPEDOE, H [1 ]
机构
[1] NATL UNIV SINGAPORE,SINGAPORE 0511,SINGAPORE
关键词
FATTY ACIDS; ADIPOSE TISSUE; CORONARY HEART DISEASE;
D O I
10.1016/0021-9150(92)90241-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The fatty acid composition of adipose tissue from 4114 men and women across 22 districts of Scotland is described. A biopsy of subcutaneous adipose tissue was obtained from the upper arm using a skin biopsy punch. Overall the proportion of saturated fatty acids was lower in women and those of monounsaturated and polyunsaturated higher than in men. There were significant effects of age on adipose tissue fatty acid composition, particularly in women, where the proportion of saturated fatty acids decreased and that of monounsaturated fatty acids increased with advancing age. The fatty acid composition of adipose tissue varied among the districts studied. The district standardised mortality ratio for coronary heart disease was positively correlated with the district mean oleic acid value and inversely correlated with the district mean linoleic acid value. This paper supports the importance of adipose tissue fatty acids as indicators of risk factor status for coronary heart disease.
引用
收藏
页码:161 / 169
页数:9
相关论文
共 15 条
[1]   NUTRIENT INTAKES OF DIFFERENT SOCIAL-CLASS GROUPS - RESULTS FROM THE SCOTTISH-HEART-HEALTH-STUDY (SHHS) [J].
BOLTONSMITH, C ;
SMITH, WCS ;
WOODWARD, M ;
TUNSTALLPEDOE, H .
BRITISH JOURNAL OF NUTRITION, 1991, 65 (03) :321-335
[2]  
BOLTONSMITH C, 1992, IN PRESS P NUTR SOC, V15
[3]   RELATIONSHIP OF DIET TO THE FATTY-ACID COMPOSITION OF HUMAN ADIPOSE-TISSUE STRUCTURAL AND STORED LIPIDS [J].
FIELD, CJ ;
ANGEL, A ;
CLANDININ, MT .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1985, 42 (06) :1206-1220
[4]   FATTY-ACID COMPOSITION OF ADIPOSE-TISSUE IN HUMANS - DIFFERENCES BETWEEN SUBCUTANEOUS SITES [J].
MALCOM, GT ;
BHATTACHARYYA, AK ;
VELEZDURAN, M ;
GUZMAN, MA ;
OALMANN, MC ;
STRONG, JP .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1989, 50 (02) :288-291
[5]   LINOLEIC-ACID CONTENT IN ADIPOSE-TISSUE AND CORONARY HEART-DISEASE [J].
RIEMERSMA, RA ;
WOOD, DA ;
BUTLER, S ;
ELTON, RA ;
OLIVER, M ;
SALO, M ;
NIKKARI, T ;
VARTIAINEN, E ;
PUSKA, P ;
GEY, F ;
RUBBA, P ;
MANCINI, M ;
FIDANZA, F .
BMJ-BRITISH MEDICAL JOURNAL, 1986, 292 (6533) :1423-1427
[6]   ADIPOSE-TISSUE LEVELS OF FATTY-ACIDS AND TOCOPHEROL IN YOUNG AND OLD WOMEN [J].
SCHAFER, L ;
OVERVAD, K ;
THORLING, EB ;
VELANDER, G .
ANNALS OF NUTRITION AND METABOLISM, 1989, 33 (06) :315-322
[7]   SUBCUTANEOUS ADIPOSE-TISSUE FATTY-ACIDS AND VITAMIN-E IN HUMANS - RELATION TO DIET AND SAMPLING SITE [J].
SCHAFER, L ;
OVERVAD, K .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1990, 52 (03) :486-490
[8]  
SINCLAIR HM, 1956, LANCET, V1, P381
[9]  
SMITH W C S, 1987, Health Bulletin (Edinburgh), V45, P211
[10]   CONCOMITANTS OF EXCESS CORONARY DEATHS - MAJOR RISK FACTOR AND LIFE-STYLE FINDINGS FROM 10,359 MEN AND WOMEN IN THE SCOTTISH-HEART-HEALTH-STUDY [J].
SMITH, WCS ;
TUNSTALLPEDOE, H ;
CROMBIE, IK ;
TAVENDALE, R .
SCOTTISH MEDICAL JOURNAL, 1989, 34 (06) :550-555