APOLIPOPROTEIN-E POLYMORPHISM AND ALZHEIMERS-DISEASE IN EASTERN FINLAND

被引：37

作者：

LEHTOVIRTA, M ^{[1
]}

HELISALMI, S ^{[1
]}

MANNERMAA, A ^{[1
]}

SOININEN, H ^{[1
]}

KOIVISTO, K ^{[1
]}

RYYNANEN, M ^{[1
]}

RIEKKINEN, P ^{[1
]}

机构：

[1] KUOPIO UNIV HOSP,DEPT OBSTET & GYNECOL,CLIN GENET UNIT,SF-70211 KUOPIO,FINLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 185卷 / 01期

关键词：

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; CHROMOSOME; 19;

D O I：

10.1016/0304-3940(94)11213-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apolipoprotein E is a polymorphic protein defined by three alleles, epsilon 2, epsilon 3 and epsilon 4. An increased frequency of the epsilon 4 allele is associated with late-onset familial and sporadic Alzheimer's disease (AD). We studied 202 Finnish AD patients and 55 age- and sex-matched controls. AD patients were divided into four subgroups; sporadic early-onset, sporadic late-onset, familial early-onset and familial late-onset disease. We found no significant differences in the epsilon 4 allele frequency between the subgroups. However, all the subgroups differed in the frequency of epsilon 4 allele detection from the controls (P < 0.0001). In the late-onset patients, the age at onset decreased from 76 to 69 as the number of epsilon 4 alleles increased from 0 to 2.

引用

页码：13 / 15

页数：3