REGIOSELECTIVE N-METHYL CARBON LITHIATION OF N-BOC-METHYLALKYLAMINES - EXPEDIENT SYNTHESIS OF UNSYMMETRICAL AMINES

被引：12

作者：

SNIECKUS, V

ROGERSEVANS, M

BEAK, P

LEE, WK

YUM, EK

FRESKOS, J

机构：

[1] UNIV ILLINOIS,DEPT CHEM,URBANA,IL 61801

[2] UNIV WATERLOO,GUELPH WATERLOO CTR GRAD WORK CHEM,WATERLOO N2L 3G1,ON,CANADA

[3] MONSANTO CO,DEPT CHEM SCI,ST LOUIS,MO 63167

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

基金：

美国国家科学基金会; 美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(00)73113-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective lithiation and functionalization at the N-methyl group of N-t-Boc-N-methylalkylamines 3 and 5 are shown with a variety of electrophiles to give products 4 and 6, respectively, thus providing a convenient methodology for the elaboration of unsymmetrical amines.

引用

收藏

页码：4067 / 4070

页数：4

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