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ARE THERE ISOENZYMES OF CYTOCHROME-C OXIDASE IN PARACOCCUS-DENITRIFICANS

被引：59
作者：
RAITIO, M
PISPA, JM
METSO, T
SARASTE, M
机构：
[1] Department of Medical Chemistry, University of Helsinki, 00170 Helsinki 17
来源：
FEBS LETTERS | 1990年 / 261卷 / 02期
关键词：
(Paracoccus); Cytochrome c 550; Cytochrome c oxidase; Gene duplication; Subunit I;
D O I：
10.1016/0014-5793(90)80609-M
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have used a gene replacement strategy to delete the previously isolated gene [(1987) EMBO J. 6, 2825-2833] for the cytochrome c oxidase subunit I from Paracoccus denitrificans. The resulting mutant was still able to synthesize active cytochrome c oxidase. This led us to look for another locus which could completely suppress the mutation. In this study we report the isolation of a second gene encoding subunit I. An open reading frame coding for cytochrome c 550 was found upstream from this gene. We suggest that there are isoenzymes of cytochrome c oxidase (cytochrome aa3) in this bacterium. © 1990.
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页码：431 / 435
页数：5
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