RATIONAL REDESIGN OF A METAL-DEPENDENT NUCLEASE - ENGINEERING THE ACTIVE-SITE OF MAGNESIUM-DEPENDENT RIBONUCLEASE-H TO FORM AN ACTIVE METAL-INDEPENDENT ENZYME

被引:26
作者
CASARENO, RLB [1 ]
LI, DW [1 ]
COWAN, JA [1 ]
机构
[1] OHIO STATE UNIV,EVANS LAB CHEM,COLUMBUS,OH 43210
关键词
D O I
10.1021/ja00149a026
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:11011 / 11012
页数:2
相关论文
共 31 条
[1]   ENGINEERING SUBTILISIN AND ITS SUBSTRATES FOR EFFICIENT LIGATION OF PEPTIDE-BONDS IN AQUEOUS-SOLUTION [J].
ABRAHMSEN, L ;
TOM, J ;
BURNIER, J ;
BUTCHER, KA ;
KOSSIAKOFF, A ;
WELLS, JA .
BIOCHEMISTRY, 1991, 30 (17) :4151-4159
[2]   MOLECULAR RECOGNITION IN CYTOCHROME-P-450 - ALTERATION OF REGIOSELECTIVE ALKANE HYDROXYLATION VIA PROTEIN ENGINEERING [J].
ATKINS, WM ;
SLIGAR, SG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (07) :2715-2717
[3]  
Black C, UNPUB
[4]   MAGNESIUM ACTIVATION OF RIBONUCLEASE-H - EVIDENCE FOR ONE CATALYTIC METAL-ION [J].
BLACK, CB ;
COWAN, JA .
INORGANIC CHEMISTRY, 1994, 33 (25) :5805-5808
[5]   QUANTITATIVE-EVALUATION OF ELECTROSTATIC AND HYDROGEN-BONDING CONTRIBUTIONS TO METAL COFACTOR BINDING TO NUCLEIC-ACIDS [J].
BLACK, CB ;
COWAN, JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (04) :1174-1178
[6]   BIOLOGICAL COORDINATION CHEMISTRY OF MAGNESIUM, SODIUM, AND POTASSIUM-IONS - PROTEIN AND NUCLEOTIDE-BINDING SITES [J].
BLACK, CB ;
HUANG, HW ;
COWAN, JA .
COORDINATION CHEMISTRY REVIEWS, 1994, 135 :165-202
[7]   CREATION OF AN NADP-DEPENDENT PYRUVATE-DEHYDROGENASE MULTIENZYME COMPLEX BY PROTEIN ENGINEERING [J].
BOCANEGRA, JA ;
SCRUTTON, NS ;
PERHAM, RN .
BIOCHEMISTRY, 1993, 32 (11) :2737-2740
[8]   CRYSTAL-STRUCTURE OF THE RIBONUCLEASE-H DOMAIN OF HIV-1 REVERSE-TRANSCRIPTASE [J].
DAVIES, JF ;
HOSTOMSKA, Z ;
HOSTOMSKY, Z ;
JORDAN, SR ;
MATTHEWS, DA .
SCIENCE, 1991, 252 (5002) :88-95
[9]   ENGINEERED METALLOREGULATION IN ENZYMES [J].
HIGAKI, JN ;
FLETTERICK, RJ ;
CRAIK, CS .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (03) :100-104
[10]   METALLOBIOCHEMISTRY OF THE MAGNESIUM-ION - CHARACTERIZATION OF THE ESSENTIAL METAL-BINDING SITE IN ESCHERICHIA-COLI RIBONUCLEASE-H [J].
HUANG, HW ;
COWAN, JA .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 219 (1-2) :253-260