PERSISTENCE OF PARVOVIRUS B19 IN SYNOVIAL-FLUID AND BONE-MARROW

被引：72

作者：

NIKKARI, S

ROIVAINEN, A

HANNONEN, P

MOTTONEN, T

LUUKKAINEN, R

YLIJAMA, T

TOIVANEN, P

机构：

[1] CENT HOSP JYVASKYLA,DEPT MED,JYVASKYLA,FINLAND

[2] TURKU UNIV,CENT HOSP,DEPT MED,DIV RHEUMATOL,TURKU,FINLAND

[3] SATALINNA HOSP,DEPT SURG,HARJAVALTA,FINLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1995年 / 54卷 / 07期

关键词：

D O I：

10.1136/ard.54.7.597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives-To determine whether parvovirus B19 (B19) persists in rheumatoid arthritis (RA). Methods-Polymerase chain reaction (PCR) was used to detect parvovirus B19 genome in the synovial fluid cells or peripheral blood mononuclear cells from 61 patients with early RA; bone marrow from one patient was also studied. The synovium or synovial fluid cells from 28 patients with advanced RA, and synovial fluid cell samples from 18 patients with reactive arthritis (as controls) were studied. Two separate sets of primers and probe were used. Results-Parvovirus B19 specific gene sequences were detected in two patients with early arthritis fulfilling the criteria for RA. Conclusion-Parvovirus B19 does not play a significant role in the aetiopatho-genesis of RA. However, a few cases of a disease indistinguishable from RA may be triggered by parvovirus B19 infection.

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页码：597 / 600

页数：4

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