ANALYSIS OF TCR USAGE IN HUMAN TUMORS - A NEW TOOL FOR ASSESSING TUMOR-SPECIFIC IMMUNE-RESPONSES

被引：97

作者：

SENSI, M

PARMIANI, G

机构：

[1] Division of Experimental Oncology D, Istituto Nazionale Tumori, I-20133 Milan

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 12期

关键词：

D O I：

10.1016/0167-5699(95)80082-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences. Here, Marialuisa Sensi and Giorgio Parmiani analyze the available information on TCR usage by T cells present in the infiltrate of histologically different tumors and suggest that the analysis of TCR sequences represents a powerful new tool to assess the in vivo immune response to growing tumors. Ultimately, this strategy may lean to the identification and manipulation of T-cell populations endowed wish antitumor reactivity.

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收藏

页码：588 / 595

页数：8

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