ANTIPSYCHOTIC EFFECTS AND TOLERANCE OF CRUDE RAUVOLFIA-VOMITORIA IN NIGERIAN PSYCHIATRIC-INPATIENTS

被引：4

作者：

OBEMBE, A

SOKOMBA, EN

SIJUWOLA, OA

OLORUNFEMI, PO

ALEMIKA, TOE

ISICHEI, CO

OGUNKEYE, OO

BANGUDU, AB

机构：

[1] UNIV JOS,COLL HLTH SCI,DEPT PHARMACOL,JOS,NIGERIA

[2] UNIV JOS,COLL HLTH SCI,DEPT PHARMACEUT MICROBIOL,JOS,NIGERIA

[3] UNIV JOS,COLL HLTH SCI,DEPT PHARMACEUT CHEM,JOS,NIGERIA

[4] UNIV JOS,COLL HLTH SCI,DEPT CHEM PATHOL,JOS,NIGERIA

[5] AHMADU BELLO UNIV,DEPT PHARMACEUT,ZARIA,NIGERIA

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 04期

关键词：

RAUVOLFIA VOMITORIA; PSYCHIATRIC PATIENTS; ANTIPSYCHOTIC EFFECT; TOLERANCE;

D O I：

10.1002/ptr.2650080406

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dried root of Rauvolfia vomitoria administered orally to 10 psychiatric patients at doses up to 800 mg/day, in divided doses, showed antipsychotic effects. The overall side effects were minimal, without serious incidence of extrapyramidal symptoms. Physical examination and laboratory parameters tend to correlate with the theory that Rauvolfia vomitoria accumulates in the plasma. The antipsychotic effects of Rauvolfia vomitoria were shown to be dose dependent when given three-times a day, with minimal side effects.

引用

页码：218 / 223

页数：6