QSAR IN TOXICOLOGY .1. PREDICTION OF AQUATIC TOXICITY

被引:125
作者
CRONIN, MTD
DEARDEN, JC
机构
[1] School of Pharmacy, Liverpool John Moores University, Liverpool, L3 3AF, Byrom Street
来源
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1995年 / 14卷 / 01期
关键词
QSAR IN TOXICOLOGY; AQUATIC TOXICITY; HAZARD ASSESSMENT; MECHANISM OF TOXICITY;
D O I
10.1002/qsar.19950140102
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A critical review is given of quantitative and qualitative structure-activity relationships (QSAR) for the prediction of some acute aquatic toxicological endpoints. Consideration is given to sources of biological data and, as in all areas of toxicology, there is concern over the validity, quality and quantity of toxicological data to model. Despite these problems it is now possible to predict the acute aquatic toxicity of unreactive chemicals to many species with considerable accuracy. Predictions for other mechanisms of toxic action become less accurate as more specific toxicities are investigated. Surprisingly little work has been performed on the prediction of toxicity of inorganic elements and their complexes, to both aquatic species and other organisms.
引用
收藏
页码:1 / 7
页数:7
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