A CHIRAL STATIONARY PHASE WHICH AFFORDS UNUSUALLY HIGH-LEVELS OF ENANTIOSELECTIVITY

被引：32

作者：

PIRKLE, WH

DEMING, KC

BURKE, JA

机构：

[1] School of Chemical Sciences, University of Illinois, Urbana, Illinois

来源：

CHIRALITY | 1991年 / 3卷 / 03期

关键词：

(S)-N-(1-NAPHTHYL)LEUCINE; N-(3,5-DINITROBENZOYL); AMINO ACIDS; DERIVATIVES; 3,5-DINITROANILIDES OF CHIRAL ACIDS;

D O I：

10.1002/chir.530030308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A chiral stationary phase (CSP) derived from N-(1-naphthyl) leucine has been prepared. This CSP is conceptually similar to the CSP derived from N-(2-naphthyl)alanine and was expected to separate the enantiomers of the same clientele of analytes as does the latter. The magnitudes of the separation factors observed on the two CSPs may differ markedly for a given analyte, the new CSP often affording much greater enantioselectivity.

引用

页码：183 / 187

页数：5

共 7 条

[1] INTERMOLECULAR H-1(H-1) NUCLEAR OVERHAUSER EFFECTS IN DIASTEREOMERIC COMPLEXES - SUPPORT FOR A CHROMATOGRAPHICALLY DERIVED CHIRAL RECOGNITION MODEL [J].