DIRECT DETERMINATION OF THE ENANTIOMERIC RATIO OF VERAPAMIL, ITS MAJOR METABOLITE NORVERAPAMIL AND GALLOPAMIL IN PLASMA BY CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：35

作者：

FIEGER, H ^{[1
]}

BLASCHKE, G ^{[1
]}

机构：

[1] UNIV MUNSTER,INST PHARMACEUT CHEM,HITTORFSTR 58-62,W-4400 MUNSTER,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 575卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80153-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two methods for the determination of the enantiomeric ratio of verapamil in plasma by high-performance liquid chromatography have been developed. On an alpha-1-acid glycoprotein chiral stationary phase (Chiral-AGP) verapamil was separated after the acetylation of the main metabolite norverapamil, which interferes with the resolution of verapamil. On an amylose tris-3,5-dimethylphenylcarbamate column (Chiralpak AD) verapamil and norverapamil were determined simultaneously without prior derivatization. Gallopamil was separated on both columns under similar conditions.

引用

页码：255 / 260

页数：6

共 13 条

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