ENDOCRINE INTERACTION BETWEEN ZINC AND PROLACTIN - AN INTERPRETATIVE REVIEW

被引:17
作者
BRANDAONETO, J [1 ]
MADUREIRA, G [1 ]
MENDONCA, BB [1 ]
BLOISE, W [1 ]
CASTRO, AVB [1 ]
机构
[1] UNIV SAO PAULO, DEPT MED, DIV ENDOCRINOL, BR-05508 SAO PAULO, BRAZIL
关键词
ZINC; PROLACTIN SYNTHESIS; STORAGE; AND SECRETION; PROLACTINOMA; NORMAL INDIVIDUALS;
D O I
10.1007/BF02788963
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Zinc plays a very important role in animal and human metabolism. Nowadays, it is one of the most extensively studied trace element, since its sphere of action has been demonstrated to be very broad. From the biochemical standpoint, it controls more than 300 different enzymes, many of them involved with intermediary metabolism, DNA and RNA synthesis, gene expression, and immunocompetence. It also plays a significant role in hormonal homeostasis, since it can interact with almost all hormones. Zn2+ is closely related to the thyroid and steroid hormones, insulin, parathormone, and pituitary hormones, particularly prolactin (PRL). Zn2+ can inhibit PRL secretion within a range of physiologically and pharmacologically relevant concentrations. This property has raised the possibility of clinical applications of zinc. In this article, we review the Literature on the subject in an attempt to provide a comprehensible general view.
引用
收藏
页码:139 / 149
页数:11
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