GROWTH CONE NEUROTRANSMITTER RECEPTOR ACTIVATION MODULATES ELECTRIC FIELD-GUIDED NERVE GROWTH

被引:50
作者
ERSKINE, L [1 ]
MCCAIG, CD [1 ]
机构
[1] UNIV ABERDEEN,MARISCHAL COLL,DEPT BIOMED SCI,ABERDEEN AB9 1AS,SCOTLAND
基金
英国惠康基金;
关键词
D O I
10.1006/dbio.1995.1285
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have studied the interactions between two nerve guidance cues, which alone induce substantial growth cone turning: endogenous neurotransmitters and small de electric fields. d-tubocurarine, a nicotinic AChR (acetylcholine receptor) antagonist, inhibited held-induced cathodal orientation of cultured neurites, whereas atropine, a muscarinic AChR blocker, and suramin, a P-2-purinoceptor antagonist, markedly enhanced the guidance properties of the applied field. These experiments implicate the activation of growth cone nicotinic AChRs by self-released acetylcholine in the mechanism underpinning electric field-induced neurite orientation and raise the possibility that growth cones release neurotransmitter prior to target interaction in order to assist their own pathfinding. Additionally, they provide the first evidence that coactivation of several neurotransmitter receptors may interact to regulate directed nerve growth. Such interaction in vivo, where guidance signals coexist, would add further levels of control to neurite guidance. (C) 1995 Academic Press, Inc.
引用
收藏
页码:330 / 339
页数:10
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