EVIDENCE FOR A CHOLINERGIC MECHANISM OF LEARNED CHANGES IN THE RESPONSES OF BARREL FIELD NEURONS OF THE AWAKE AND UNDRUGGED RAT

被引:50
作者
DELACOUR, J
HOUCINE, O
COSTA, JC
机构
[1] Laboratoire de Psychophysiologie, Université Paris 7
关键词
D O I
10.1016/0306-4522(90)90299-J
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Due to its functional importance and its large and highly differentiated central projections, the vibrissal system of rodents is a prime object for the study of sensory plasticity, especially at the cortical level: the representation of vibrissae in the "barrel field", a part of the somatic cortex, is exceptionally precise and is susceptible to experience-induced changes. In a previous series of experiments, we found that a sensory-sensory conditioning procedure, pairing two vibrissal stimulations, produces significant changes in responses of single neurons of the barrel field in the chronic awake and undrugged rat: 1. (1) the appearance of an excitatory response to a stimulus that was ineffective before pairing ("conditioned response"). 2. (2) the modifications of pre-existing responses consisting of the suppression of afferent inhibition and the appearance of long-latency excitatory components. We report here that the micro-iontophoretic application of atropine abolishes "conditioned responses" and restores afferent inhibition. Acetylcholine facilitates an enlargement of the receptive field and induces a sustained mode of discharge to stimuli. These data provide a new and direct support to the hypothesis that cholinergic mechanisms are involved in the sensory cortex plasticity. © 1990.
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页码:1 / 8
页数:8
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