COLLAGENASE ACTIVITY IN THE CERVIX OF NONPREGNANT AND PREGNANT-WOMEN

被引:26
作者
OSMERS, R
RATH, W
ADELMANNGRILL, BC
FITTKOW, C
SEVERENYI, M
KUHN, W
机构
[1] DEBRECEN UNIV MED,DEPT OBSTET & GYNECOL,H-4012 DEBRECEN,HUNGARY
[2] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY
关键词
Cervix uteri; Collagenase; Parturition; Pregnancy;
D O I
10.1007/BF02389578
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Cervical biopsies were obtained from non pregnant patients and from pregnant at various stages of gestation and during labour. The tissues were extract with a Ca++-containing buffer, and collagenase activity was determined in these extracts using a solid phase assay in which triple helical125I-labelled collagen was cleaved. Collagenase was detected in all samples but significantly elevated activity was only present in labour at 6-8 cm cervical dilatation. This provides direct evidence for the crucial role of specific collagen degradation during cervical ripening and dilatation. © 1990 Springer-Verlag.
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页码:75 / 80
页数:6
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