SEQUENCE DETERMINATION OF VARIABLE REGION GENES OF 2 HUMAN MONOCLONAL-ANTIBODIES AGAINST NEISSERIA-MENINGITIDIS

被引：7

作者：

AVILA, MA ^{[1
]}

VAZQUES, J ^{[1
]}

DANIELSSON, L ^{[1
]}

DECOSSIO, MEF ^{[1
]}

BORREBAECK, CAK ^{[1
]}

机构：

[1] LUND UNIV,DEPT IMMUNOTECHNOL,POB 7031,S-22007 LUND 7,SWEDEN

来源：

GENE | 1993年 / 127卷 / 02期

关键词：

RECOMBINANT DNA; POLYMERASE CHAIN REACTION; IMMUNOGLOBULIN;

D O I：

10.1016/0378-1119(93)90734-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nucleotide sequences for the variable regions of both the heavy and light chains for two human monoclonal antibodies have been determined. Both antibodies are directed against an outer membrane protein of Neisseria meningitidis, and their genes show a low resemblance to germline sequences.

引用

页码：273 / 274

页数：2

共 3 条

[1] HUMAN MONOCLONAL-ANTIBODIES AGAINST AN EPITOPE ON THE CLASS 5C OUTER-MEMBRANE PROTEIN COMMON TO MANY PATHOGENIC STRAINS OF NEISSERIA-MENINGITIDIS [J].

DECOSSIO, MEF ;

OHLIN, M ;

LLANO, M ;

SELANDER, B ;

CRUZ, S ;

DELVALLE, J ;

BORREBAECK, CAK .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (06) :1322-1328

[2]

Kabat E.A., 1991, SEQUENCES PROTEINS I, V5th

[3] POLYMERASE CHAIN-REACTION USING MIXED PRIMERS - CLONING OF HUMAN MONOCLONAL-ANTIBODY VARIABLE REGION GENES FROM SINGLE HYBRIDOMA CELLS [J].

LARRICK, JW ;

DANIELSSON, L ;

BRENNER, CA ;

WALLACE, EF ;

ABRAHAMSON, M ;

FRY, KE ;

BORREBAECK, CAK .

BIO-TECHNOLOGY, 1989, 7 (09) :934-938

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