INVASIVENESS OF ENDOMETRIOTIC CELLS IN-VITRO

被引：144

作者：

GAETJE, R

KOTZIAN, S

HERRMANN, G

BAUMANN, R

STARZINSKIPOWITZ, A

机构：

[1] UNIV FRANKFURT,D-60054 FRANKFURT,GERMANY

[2] UNIV FRANKFURT KLINIKUM,ZENTRUM FRAUENHEILKUNDE & GEBURTSCHILFE,W-6000 FRANKFURT,GERMANY

[3] UNIV FRANKFURT KLINIKUM,ZENTRUM SENCKENBERG PATHOL,W-6000 FRANKFURT,GERMANY

来源：

LANCET | 1995年 / 346卷 / 8988期

关键词：

D O I：

10.1016/S0140-6736(95)92474-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogenesis of endometriosis is not known. The currently favoured theory is that viable endometrial cells, shed from the endometrium into the pelvic cavity by retrograde menstruation, reattach and invade other tissues. We used a collagen gel invasion assay to assess invasive potential of endometriotic cells. The invasion indices of cells from peritoneal endometriotic lesions and a metastatic bladder carcinoma cell line (EJ28) were similar (2.2-15.6 vs 8.4-11.6) whereas cells from normal endometrium and non-metastatic carcinoma cells (RT112) were non-invasive (indices <1). Invasiveness of endometriotic cells might contribute to the pathogenesis of endometriosis.

引用

页码：1463 / 1464

页数：2

共 9 条

[1]

BATTISTA G, 1991, OBSTET GYNECOL SURV, V46, P374

[2] E-CADHERIN-MEDIATED CELL CELL-ADHESION PREVENTS INVASIVENESS OF HUMAN CARCINOMA-CELLS [J].