TYRAMINE CONJUGATION DEFICIT IN PATIENTS WITH CHRONIC IDIOPATHIC TEMPOROMANDIBULAR-JOINT AND OROFACIAL PAIN

被引：17

作者：

AGHABEIGI, B

FEINMANN, C

GLOVER, V

GOODWIN, B

HANNAH, P

HARRIS, M

SANDLER, M

WASIL, M

机构：

[1] UCL EASTMAN DENT HOSP, INST DENT SURG, JOINT DEPT MAXILLOFACIAL SURG & ORAL MED, LONDON WC1X 8LD, ENGLAND

[2] UNIV COLL HOSP LONDON, JOINT DEPT MAXILLOFACIAL SURG & ORAL MED, WC1 LONDON, ENGLAND

[3] QUEEN CHARLOTTES & CHELSEA HOSP, DEPT CHEM PATHOL, LONDON W6 0XG, ENGLAND

来源：

PAIN | 1993年 / 54卷 / 02期

关键词：

CHRONIC PAIN; PATHOPHYSIOLOGY; FACIAL PAIN; TYRAMINE; DEPRESSION;

D O I：

10.1016/0304-3959(93)90204-3

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

This study was carried out to explore the value of the tyramine conjugation test, an established trait marker for 'endogenous unipolar depression', in patients with chronic idiopathic temporomandibular joint and orofacial pain. Our results show that the pain patients excrete significantly lower amounts of tyramine sulphate than controls (P < 0.0004). Psychiatric assessment by the structured clinical interview for the diagnosis of mental disorders according to DSM-III-R revealed that 48% of the patients had a history of depression and 10% were currently depressed. However, the never-depressed group of patients had the lowest tyramine sulphate excretion values. These findings suggest that a common biological abnormality underlies the pathogenesis of both chronic idiopathic facial pain and depression.

引用

页码：159 / 163

页数：5

共 32 条

[21] THE MANAGEMENT OF PSYCHOGENIC OROFACIAL PAIN [J].