SELENIUM AND GLUTATHIONE-PEROXIDASE VARIATIONS INDUCED BY POLYUNSATURATED FATTY-ACIDS ORAL SUPPLEMENTATION IN HUMANS

被引:34
作者
BELLISOLA, G
GALASSINI, S
MOSCHINI, G
POLI, G
PERONA, G
GUIDI, G
机构
[1] COC, CLIN CHEM LAB, I-37067 VALEGGIO SM, ITALY
[2] UNIV VERONA, INST CLIN CHEM, I-37100 VERONA, ITALY
[3] UNIV VERONA, INST BIOL CHEM, I-37100 VERONA, ITALY
[4] UNIV PADUA, DEPT PHYS, I-35100 PADUA, ITALY
[5] IST NAZL FIS NUCL, LAB NAZL LEGNARO, PADUA, ITALY
[6] UNIV VERONA, INST MED PATHOL, DIV HAEMATOL, I-37100 VERONA, ITALY
关键词
BLOOD PLATELETS; ERYTHROCYTES; GLUTATHIONE PEROXIDASE; SELENIUM; SERUM SELENIUM; FISH OIL;
D O I
10.1016/S0009-8981(05)80002-6
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Serum and erythrocyte selenium, erythrocyte and platelet glutathione-peroxidase (GSH-Px) activities, and erythrocyte reduced glutathione (GSH) content were measured in 25 healthy adult individuals before and after daily supplementation with 20 ml of fish oil for 10 weeks. Serum-Se decreased from 0.83 +/- 0.01-mu-mol/l to 0.75 +/- 0.02-mu-mol/l (mean +/- S.E.M.) (P < 0.0l); erythrocyte-Se decreased from 4.39 +/- 0.17 nmol/g hemoglobin (Hb) to 2.83 +/- 0.15 nmol/g (P < 0.001). GSH-Px activities increased both in erythrocytes (6.93 +/- 0.24 iu/g vs 8.18 +/- 0.27 iu/g Hb, P < 0.01) and in platelets (69.2 +/- 2.8 iu/g vs 90.9 +/- 3.6 iu/g protein, P < 0.001). The concentration of GSH in erythrocytes fell from 9.56 +/- 0.29-mu-mol/g Hb to 5.90 +/- 0.30-mu-mol/g Hb (P < 0.001). The effects on plasma lipids were evident only for triglycerides (before 1.96 +/- 0.16 mmol/l, after 1.75 +/- 0.14 mmol/l, P < 0.00 1). We hypothesise the enrichment of erythrocyte and platelet membranes with polyunsaturated fatty acids (PUFAs), following fish oil intake, can generate increased amounts of lipid peroxides and thus allosterically activate GSH-Px: with time this is harmful for the integrity of the enzyme molecule and Se release may result. We suggest that the Se status of individuals given PUFAs is assessed before and during intake; Se supplements should only be given when serum and/or erythrocyte Se are reduced.
引用
收藏
页码:75 / 85
页数:11
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