MOLECULAR-CLONING OF A NOVEL CALCIUM-BINDING PROTEIN STRUCTURALLY RELATED TO HIPPOCALCIN FROM HUMAN BRAIN AND CHROMOSOMAL MAPPING OF ITS GENE

被引：16

作者：

KOBAYASHI, M

TAKAMATSU, K

FUJISHIRO, M

SAITOH, S

NOGUCHI, T

机构：

[1] TOHO UNIV,SCH MED,DEPT PHYSIOL,OHTA KU,TOKYO 143,JAPAN

[2] TOMY SEIKO CORP,DIV RES & DEV,NERIMA KU,TOKYO 176,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1222卷 / 03期

关键词：

CLONING; NUCLEOTIDE SEQUENCE; CHROMOSOMAL MAPPING; HIPPOCALCIN-LIKE PROTEIN; BRAIN; (HUMAN);

D O I：

10.1016/0167-4889(94)90062-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone (hHLP2) encoding a novel calcium-binding protein structurally related to hippocalcin has been isolated from the human hippocampus cDNA library. The primary structure consists of 193 amino acids, and contains three EF-hand structures and a possible NH2-terminal myristoylation site. A single transcript at a position corresponding to 1.7 kilobases was detected only in the brain. The hHLP2 gene was mapped to human chromosome 2.

引用

收藏

页码：515 / 518

页数：4

相关论文

共 17 条

[1] RECOVERIN - A CALCIUM SENSITIVE ACTIVATOR OF RETINAL ROD GUANYLATE-CYCLASE [J].

DIZHOOR, AM ;

RAY, S ;

KUMAR, S ;

NIEMI, G ;

SPENCER, M ;

BROLLEY, D ;

WALSH, KA ;

PHILIPOV, PP ;

HURLEY, JB ;

STRYER, L .

SCIENCE, 1991, 251 (4996) :915-918

[2] ACYLATION OF VIRAL AND EUKARYOTIC PROTEINS [J].

GRAND, RJA .

BIOCHEMICAL JOURNAL, 1989, 258 (03) :625-638

[3] THE EFFECT OF RECOVERIN-LIKE CALCIUM-BINDING PROTEINS ON THE PHOTORESPONSE OF RETINAL RODS [J].

GRAYKELLER, MP ;

POLANS, AS ;

PALCZEWSKI, K ;

DETWILER, PB .

NEURON, 1993, 10 (03) :523-531

[4] NEUROCALCIN FAMILY - A NOVEL CALCIUM-BINDING PROTEIN ABUNDANT IN BOVINE CENTRAL-NERVOUS-SYSTEM [J].

HIDAKA, H ;

OKAZAKI, K .

NEUROSCIENCE RESEARCH, 1993, 16 (02) :73-77

[5] MOLECULAR-CLONING OF 2 ADDITIONAL MEMBERS OF THE NEURAL VISININ-LIKE CA2+-BINDING PROTEIN GENE FAMILY [J].

KAJIMOTO, Y ;

SHIRAI, Y ;

MUKAI, H ;

KUNO, T ;

TANAKA, C .

JOURNAL OF NEUROCHEMISTRY, 1993, 61 (03) :1091-1096

[6] CALCIUM-DEPENDENT REGULATION OF CYCLIC-GMP PHOSPHODIESTERASE BY A PROTEIN FROM FROG RETINAL RODS [J].

KAWAMURA, S ;

MURAKAMI, M .

NATURE, 1991, 349 (6308) :420-423

[7] RHODOPSIN PHOSPHORYLATION AS A MECHANISM OF CYCLIC-GMP PHOSPHODIESTERASE REGULATION BY S-MODULIN [J].

KAWAMURA, S .

NATURE, 1993, 362 (6423) :855-857

[8]

KAWAMURA S, 1993, J BIOL CHEM, V268, P14579

[9] MOLECULAR-CLONING OF HIPPOCALCIN, A NOVEL CALCIUM-BINDING PROTEIN OF THE RECOVERIN FAMILY EXCLUSIVELY EXPRESSED IN HIPPOCAMPUS [J].

KOBAYASHI, M ;

TAKAMATSU, K ;

SAITOH, S ;

MIURA, M ;

NOGUCHI, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 189 (01) :511-517

[10] COMPILATION AND ANALYSIS OF SEQUENCES UPSTREAM FROM THE TRANSLATIONAL START SITE IN EUKARYOTIC MESSENGER-RNAS [J].

KOZAK, M .

NUCLEIC ACIDS RESEARCH, 1984, 12 (02) :857-872