RATIONAL DESIGN OF ENZYME-INHIBITORS - MULTISUBSTRATE ANALOG INHIBITORS

[1] SYNTHESIS AND EVALUATION OF SOME STABLE MULTISUBSTRATE ADDUCTS AS INHIBITORS OF CATECHOL O-METHYLTRANSFERASE [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (11) : 1271 - 1277

[2] Baker BR, 1967, DESIGN ACTIVE SITE D

[3] PHOSPHONAMIDATES AS TRANSITION-STATE ANALOG INHIBITORS OF THERMOLYSIN [J]. BIOCHEMISTRY, 1983, 22 (20) : 4618 - 4624

[4] PROBING THE THYMIDYLATE SYNTHASE ACTIVE-SITE WITH BISUBSTRATE ANALOG INHIBITORS [J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1988, 7 (01) : 103 - 115

[5] MULTISUBSTRATE ADDUCTS AS POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE DEPENDENT METHYLASES - INHIBITION OF INDOLE N-METHYLTRANSFERASE BY (5'-DEOXYADENOSYL)[3-(3-INDOLYL)PROP-1-YL]METHYLSULFONIUM AND (5'-DEOXYADENOSYL)[4-(3-INDOLYL)BUT-1-YL]METHYLSULFONIUM SALTS [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (10) : 1470 - 1477

[6] INHIBITION OF VACCINIA RNA GUANINE 7-METHYLTRANSFERASE BY COMPOUNDS DESIGNED AS MULTISUBSTRATE ADDUCTS [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (02) : 142 - 145

[7] ON THE MECHANISM OF ACTION OF FOLATE-REQUIRING AND BIOPTERIN-REQUIRING ENZYMES [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 : 227 - 251

[8] S-ADENOSYL-L-METHIONINE-DEPENDENT MACROMOLECULE METHYLTRANSFERASES - POTENTIAL TARGETS FOR THE DESIGN OF CHEMOTHERAPEUTIC-AGENTS [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (04) : 347 - 357

[9] BROOM AD, 1986, FASEB J, V45, P2779

[10] BURKOWSKI RM, 1980, CANCER TREATMENT REP, V64, P1387

[1] SYNTHESIS AND EVALUATION OF SOME STABLE MULTISUBSTRATE ADDUCTS AS INHIBITORS OF CATECHOL O-METHYLTRANSFERASE [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (11) : 1271 - 1277

[2] Baker BR, 1967, DESIGN ACTIVE SITE D

[3] PHOSPHONAMIDATES AS TRANSITION-STATE ANALOG INHIBITORS OF THERMOLYSIN [J]. BIOCHEMISTRY, 1983, 22 (20) : 4618 - 4624

[4] PROBING THE THYMIDYLATE SYNTHASE ACTIVE-SITE WITH BISUBSTRATE ANALOG INHIBITORS [J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1988, 7 (01) : 103 - 115

[5] MULTISUBSTRATE ADDUCTS AS POTENTIAL INHIBITORS OF S-ADENOSYLMETHIONINE DEPENDENT METHYLASES - INHIBITION OF INDOLE N-METHYLTRANSFERASE BY (5'-DEOXYADENOSYL)[3-(3-INDOLYL)PROP-1-YL]METHYLSULFONIUM AND (5'-DEOXYADENOSYL)[4-(3-INDOLYL)BUT-1-YL]METHYLSULFONIUM SALTS [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (10) : 1470 - 1477

[6] INHIBITION OF VACCINIA RNA GUANINE 7-METHYLTRANSFERASE BY COMPOUNDS DESIGNED AS MULTISUBSTRATE ADDUCTS [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (02) : 142 - 145

[7] ON THE MECHANISM OF ACTION OF FOLATE-REQUIRING AND BIOPTERIN-REQUIRING ENZYMES [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1980, 49 : 227 - 251

[8] S-ADENOSYL-L-METHIONINE-DEPENDENT MACROMOLECULE METHYLTRANSFERASES - POTENTIAL TARGETS FOR THE DESIGN OF CHEMOTHERAPEUTIC-AGENTS [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (04) : 347 - 357

[9] BROOM AD, 1986, FASEB J, V45, P2779

[10] BURKOWSKI RM, 1980, CANCER TREATMENT REP, V64, P1387