REGIOCONTROL IN NUCLEOPHILIC RING-OPENING OF CHIRAL EPOXIDES OF CHEMOENZYMATIC ORIGIN

被引：13

作者：

GUANTI, G ^{[1
]}

MERLO, V ^{[1
]}

NARISANO, E ^{[1
]}

机构：

[1] CNR,CTR STUDIO CHIM COMPOSTI CICLOALIFATICI & AROMATI,I-16132 GENOA,ITALY

来源：

TETRAHEDRON | 1994年 / 50卷 / 42期

关键词：

D O I：

10.1016/S0040-4020(01)89574-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Homochiral cis epoxides derived from enzymatically asymmetrized tris(hydroxymethyl)methane equivalents (THYM*) are regioselectively opened by carbon based-nucleophiles (alkyl groups or cyanides) and halides in the presence of Lewis acids. Enantio- and diastereodivergent synthesis of branched triols is reported.

引用

页码：12245 / 12258

页数：14

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