EPSTEIN-BARR-VIRUS INFECTED T-LYMPHOCYTES IN EPSTEIN-BARR-VIRUS ASSOCIATED HEMOPHAGOCYTIC SYNDROME

被引：164

作者：

KAWAGUCHI, H

MIYASHITA, T

HERBST, H

NIEDOBITEK, G

ASADA, M

TSUCHIDA, M

HANADA, R

KINOSHITA, A

SAKURAI, M

KOBAYASHI, N

MIZUTANI, S

机构：

[1] NATL CHILDRENS MED RES CTR,DEPT VIROL,3-35-31 TAISHIDO,SETAGAYA KU,TOKYO 154,JAPAN

[2] FREE UNIV BERLIN,KLINIKUM STEGLITZ,INST PATHOL,W-1000 BERLIN 45,GERMANY

[3] IBARAKI CHILDRENS HOSP,DEPT INTERNAL MED,IBARAKI 31141,JAPAN

[4] SAITAMA CHILDRENS MED CTR,DEPT HEMATOL ONCOL,SAITAMA 339,JAPAN

[5] KEIO UNIV,SCH MED,DEPT PEDIAT,TOKYO 160,JAPAN

[6] MIE UNIV,SCH MED,DEPT PEDIAT,TSU,MIE 514,JAPAN

[7] NATL CHILDRENS HOSP,TOKYO 154,JAPAN

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 92卷 / 03期

关键词：

T-CELLS; CD45RO ANTIGEN; EBER; MALIGNANT HISTIOCYTOSIS; HISTIOCYTIC MEDULLARY RETICULOSIS;

D O I：

10.1172/JCI116721

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The clonal composition of EBV-infected cells was examined in three cases of EBV-associated hemophagocytic syndrome by analysis of the heterogeneity of terminal repetitive sequences in the EBV genome, indicating monoclonal expansion of EBV-infected cells in all cases. Involvement of T lymphoid cells was determined by in situ hybridization using S-35-labeled RNA probes specific for the small EBV-encoded nuclear RNAs, EBER1 and EBER2, in combination with immunostaining for the TCR-beta chain, CD45RO, CD20, CD30 and CD68 antigens in these three cases. The majority of lymphoid cells showing EBER transcripts were stained by antibodies against CD45RO and T cell receptor-beta. In contrast, EBER-specific signals were not detectable on B cells or hemophagocytic cells. These data support the concept that EBV-associated T cell proliferation is a primary feature of EBV-AHS.

引用

页码：1444 / 1450

页数：7

共 37 条

[1] A6 - A NEW 45RO MONOCLONAL-ANTIBODY FOR IMMUNOSTAINING OF PARAFFIN-EMBEDDED TISSUES [J].

BERTI, E ;

AVERSA, GG ;

SOLIGO, D ;

CATTORETTI, G ;

DELIA, D ;

AIELLO, A ;

PARRAVICINI, C ;

HALL, BM ;

CAPUTO, R .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1991, 95 (02) :188-193

[2] FLOW CYTOMETRIC ANALYSIS OF EPSTEIN-BARR-VIRUS (EBV) LATENT MEMBRANE-PROTEIN EXPRESSION IN EBV-INFECTED RAJI CELLS [J].

BOOS, H ;

STOEHR, M ;

SAUTER, M ;

MUELLERLANTZSCH, N .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :1811-1815

[3]

BUDD RC, 1987, J IMMUNOL, V138, P3583

[4]

BYRNE GE, 1973, GANN MONOGRAPH CANCE, V15, P145

[5]

CLEARY ML, 1988, BLOOD, V72, P349

[6]

CRAIG F, 1991, AM J CLIN PATHOL, V97, P189

[7]

FALINI B, 1990, BLOOD, V75, P434

[8] DEVELOPMENTALLY REGULATED REARRANGEMENT AND EXPRESSION OF GENES ENCODING THE T-CELL RECEPTOR-T3 COMPLEX [J].

FURLEY, AJ ;

MIZUTANI, S ;

WEILBAECHER, K ;

DHALIWAL, HS ;

FORD, AM ;

CHAN, LC ;

MOLGAARD, HV ;

TOYONAGA, B ;

MAK, T ;

VANDENELSEN, P ;

GOLD, D ;

TERHORST, C ;

GREAVES, MF .

CELL, 1986, 46 (01) :75-87

[9]

HANDEN DG, 1985, CYTOGENET CELL GENET, V21

[10] EPSTEIN-BARR VIRUS IN NASAL T-CELL LYMPHOMAS IN PATIENTS WITH LETHAL MIDLINE GRANULOMA [J].

HARABUCHI, Y ;

YAMANAKA, N ;

KATAURA, A ;

IMAI, S ;

KINOSHITA, T ;

MIZUNO, F ;

OSATO, T .

LANCET, 1990, 335 (8682) :128-130

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