ALTERNATIVE SPLICING OF AMPA RECEPTOR SUBUNITS - REGULATION IN CLONAL CELL-LINES

被引：4

作者：

CHRISTNACHER, A ^{[1
]}

SOMMER, B ^{[1
]}

机构：

[1] SANDOZ PHARMA LTD,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

来源：

FEBS LETTERS | 1995年 / 373卷 / 01期

关键词：

AMPA; GLUR-A TO GLUR-D; FLIP; FLOP; ALTERNATIVE SPLICING;

D O I：

10.1016/0014-5793(95)01016-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing of AMPA receptors was investigated in rat PC12 and human SH-SY5Y cells. PC12 cells predominantly expressed GluR-B flip mRNA before and after differentiation, In SH-SY5Y cells, each AMPA-receptor subunit showed a distinct splice variant expression profile throughout differentiation. GluR-B mRNA was comparable in expression levels for flip and flop splice variants. In the other AMPA-receptor subunit transcripts the flip form was the more prominent splice variant. After three days post induction a transient elevation of GluR-B and -D flop mRNA expression could be observed.

引用

页码：93 / 96

页数：4

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