5-YEAR FOLLOW-UP-STUDY ON PLASMA-INSULIN LEVELS IN NEWLY DIAGNOSED NIDDM PATIENTS AND NONDIABETIC SUBJECTS

被引:55
作者
NISKANEN, LK [1 ]
UUSITUPA, MI [1 ]
SARLUND, H [1 ]
SIITONEN, O [1 ]
PYORALA, K [1 ]
机构
[1] UNIV KUOPIO, DEPT CLIN NUTR, SF-70210 KUOPIO, FINLAND
关键词
D O I
10.2337/diacare.13.1.41
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A representative group of middle-aged (45- to 64-yr-old) patients with non-insulin-dependent diabetes mellitus (NIDDM) (n = 133; 70 men, 63 women) were examined at the time of diagnosis and 5 yr afterward for metabolic control and insulin response to oral glucose; 144 nondiabetic control subjects (62 men, 82 women) were similarly examined twice between 5-yr intervals. At the 5-yr examination, 56 of the diabetic patients (36 men, 20 women) were on diet therapy only, 60 (27 men, 33 women) received oral antidiabetic drugs, and 5 were treated with insulin. The metabolic control of diabetic patients was poor at the time of diagnosis and 5-yr examination. Fasting plasma insulin levels were higher in diabetic patients than in control subjects both at baseline (23 ± 2 vs. 14 ± 1 mU/L, P < 0.01, for men; 26 ± 2 vs. 15 ± 1 mU/L, NS, for women) and 5-yr examination (19 ± 1 vs. 16 ± 2 mU/L, NS, for men; 29 ± 5 vs. 15 ± 1 mU/L, P < 0.05, for women). The frequency of insulin deficiency in diabetic patients based on a postglucagon (1 mg i.v.) C-peptide level <0.60 nM was 3.3% at the 5-yr examination, indicating that true insulin deficiency was uncommon during the first years after diagnosis of diabetes in middle-aged subjects.
引用
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页码:41 / 48
页数:8
相关论文
共 34 条
[11]  
KORHONEN T, 1987, ACTA MED SCAND, V222, P323
[12]   INCREASE IN INSULIN-RESPONSE AFTER TREATMENT OF OVERT MATURITY-ONSET DIABETES IN INDEPENDENT OF THE MODE OF TREATMENT [J].
KOSAKA, K ;
KUZUYA, T ;
AKANUMA, Y ;
HAGURA, R .
DIABETOLOGIA, 1980, 18 (01) :23-28
[13]  
LAAKSO M, 1988, ACTA MED SCAND, V223, P61
[14]   PREVALENCE OF INSULIN DEFICIENCY AMONG INITIALLY NON-INSULIN-DEPENDENT MIDDLE-AGED DIABETIC INDIVIDUALS [J].
LAAKSO, M ;
SARLUND, H ;
PYORALA, K .
DIABETES CARE, 1986, 9 (03) :228-231
[15]   ATHEROSCLEROTIC VASCULAR-DISEASE AND ITS RISK-FACTORS IN NON-INSULIN-DEPENDENT DIABETIC AND NONDIABETIC SUBJECTS IN FINLAND [J].
LAAKSO, M ;
RONNEMAA, T ;
PYORALA, K ;
KALLIO, V ;
PUUKKA, P ;
PENTTILA, I .
DIABETES CARE, 1988, 11 (06) :449-463
[16]   IMPAIRED GLUCOSE-TOLERANCE AS A DISORDER OF INSULIN ACTION - LONGITUDINAL AND CROSS-SECTIONAL STUDIES IN PIMA-INDIANS [J].
LILLIOJA, S ;
MOTT, DM ;
HOWARD, BV ;
BENNETT, PH ;
YKIJARVINEN, H ;
FREYMOND, D ;
NYOMBA, BL ;
ZURLO, F ;
SWINBURN, B ;
BOGARDUS, C .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (19) :1217-1225
[17]   IRI-SECRETION IN MOD WITH AND WITHOUT SU (5 YEAR CONTROL) [J].
LOHMANN, D ;
VERLOHREN, HJ .
HORMONE AND METABOLIC RESEARCH, 1980, 12 (12) :702-703
[18]  
MADSBAD S, 1981, ACTA MED SCAND, V210, P153
[19]   CLINICAL-PHARMACOLOGY OF SULFONYLUREAS [J].
MELANDER, A .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1987, 36 (02) :12-16
[20]  
NIELSEN NV, 1986, DIABETES RES CLIN EX, V3, P475