NUCLEUS-ACCUMBENS DOPAMINE-CCK INTERACTIONS IN PSYCHOSTIMULANT REWARD AND RELATED BEHAVIORS

被引：72

作者：

VACCARINO, FJ ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT PSYCHIAT, TORONTO M5S 1A1, ON, CANADA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1994年 / 18卷 / 02期

基金：

英国医学研究理事会;

关键词：

PSYCHOSTIMULANT; DOPAMINE; CCK; REWARD; LOCOMOTOR ACTIVITY; FEEDING; NUCLEUS ACCUMBENS; AMPHETAMINE; COCAINE; INDIVIDUAL DIFFERENCES;

D O I：

10.1016/0149-7634(94)90025-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present paper provides an overview of dopamine (DA) and cholecystokinin (CCK) mechanisms that contribute to psychostimulant reward-related behaviors. Three different behavioral paradigms are focused on: intravenous psychostimulant reward, psychostimulant-induced locomotor activity, and psychostimulant-induced feeding. Based on evidence derived from these different behavioral paradigms, this paper reviews data indicating that nucleus accumbens CCK and DA play an important role in mediating reward. Neurobiological mechanisms are proposed to explain the functional relationship between CCK and DA in the nucleus accumbens.

引用

页码：207 / 214

页数：8

共 96 条

[1]

BARRETT RW, 1989, MOL PHARMACOL, V36, P285

[2] THE DISTRIBUTION OF CHOLECYSTOKININ IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM OF THE RAT AS DETERMINED BY RADIOIMMUNOASSAY [J].

BEINFELD, MC ;

MEYER, DK ;

ESKAY, RL ;

JENSEN, RT ;

BROWNSTEIN, MJ .

BRAIN RESEARCH, 1981, 212 (01) :51-57

[3] REVERSAL BY CHOLECYSTOKININ OF APOMORPHINE-INDUCED INHIBITION OF DOPAMINE RELEASE IN THE NUCLEUS-ACCUMBENS OF THE RAT [J].

BLAHA, CD ;

PHILLIPS, AG ;

LANE, RF .

REGULATORY PEPTIDES, 1987, 17 (06) :301-310

[4]

BRANCHEREAU P, 1992, J PHARMACOL EXP THER, V260, P1433

[5] CONTRIBUTIONS OF DOPAMINE TERMINAL AREAS TO AMPHETAMINE-INDUCED ANOREXIA AND ADIPSIA [J].

CARR, GD ;

WHITE, NM .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (01) :17-22

[6] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST [J].

CHANG, RSL ;

LOTTI, VJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4923-4926

[7]

CHANG RSL, 1989, MOL PHARMACOL, V35, P803

[8] FACILITORY AND INHIBITORY EFFECTS OF NUCLEUS ACCUMBENS AMPHETAMINE ON FEEDING [J].

COLLE, LM ;

WISE, RA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1988, 537 :491-492

[9] ANTAGONIST TREATMENT IN NUCLEUS ACCUMBENS OR PERIAQUEDUCTAL GREY AFFECTS HEROIN SELF-ADMINISTRATION [J].

CORRIGALL, WA ;

VACCARINO, FJ .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 30 (02) :443-450

[10]

CRAWLEY J N, 1991, Society for Neuroscience Abstracts, V17, P1063

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