FOLDING OF NASCENT POLYPEPTIDE-CHAINS IN A HIGH-MOLECULAR-MASS ASSEMBLY WITH MOLECULAR CHAPERONES

被引：575

作者：

FRYDMAN, J

NIMMESGERN, E

OHTSUKA, K

HARTL, FU

机构：

[1] MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,CELLULAR BIOCHEM & BIPHYS PROGRAM,NEW YORK,NY 10021

[3] AICHI CANC CTR,EXPTL RADIOL LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

来源：

NATURE | 1994年 / 370卷 / 6485期

关键词：

D O I：

10.1038/370111a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The folding of polypeptides emerging from ribosomes was analysed in a mammalian translation system using firefly luciferase as a model protein. The growing polypeptide interacts with a specific set of molecular chaperones, including Hsp70, the DnaJ homologue Hsp40 and the chaperonin TRiC. The ordered assembly of these components on the nascent chain forms a high molecular mass complex that allows the cotranslational formation of protein domains and the completion of folding once the chain is released from the ribosome.

引用

收藏

页码：111 / 117

页数：7

相关论文

共 50 条

[21] MOLECULAR CHAPERONES IN PROTEIN-FOLDING - THE ART OF AVOIDING STICKY SITUATIONS [J].

HARTL, FU ;

HLODAN, R ;

LANGER, T .

TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (01) :20-25

[22]

HATTORI H, 1993, J CELL SCI, V104, P629

[23] HOMOLOGOUS PLANT AND BACTERIAL PROTEINS CHAPERONE OLIGOMERIC PROTEIN ASSEMBLY [J].

HEMMINGSEN, SM ;

WOOLFORD, C ;

VANDERVIES, SM ;

TILLY, K ;

DENNIS, DT ;

GEORGOPOULOS, CP ;

HENDRIX, RW ;

ELLIS, RJ .

NATURE, 1988, 333 (6171) :330-334

[24] CONTROL OF FOLDING AND MEMBRANE TRANSLOCATION BY BINDING OF THE CHAPERONE DNAJ TO NASCENT POLYPEPTIDES [J].

HENDRICK, JP ;

LANGER, T ;

DAVIS, TA ;

HARTL, FU ;

WIEDMANN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10216-10220

[25] PROTEIN FOLDING IN THE CELL - FUNCTIONS OF 2 FAMILIES OF MOLECULAR CHAPERONE, HSP 60 AND TF55-TCP1 [J].

HORWICH, AL ;

WILLISON, KR .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1993, 339 (1289) :313-326

[26] FOLDING AND ASSOCIATION OF PROTEINS [J].

JAENICKE, R .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1987, 49 (2-3) :117-237

[27]

JAGUS R, 1987, METHOD ENZYMOL, V152, P267

[28] FIREFLY LUCIFERASE IS TARGETED TO PEROXISOMES IN MAMMALIAN-CELLS [J].

KELLER, GA ;

GOULD, S ;

DELUCA, M ;

SUBRAMANI, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) :3264-3268

[29] IDENTIFICATION OF 6 TCP-1-RELATED GENES ENCODING DIVERGENT SUBUNITS OF THE TCP-1-CONTAINING CHAPERONIN [J].

KUBOTA, H ;

HYNES, G ;

CARNE, A ;

ASHWORTH, A ;

WILLISON, K .

CURRENT BIOLOGY, 1994, 4 (02) :89-99

[30] DIFFERENT CONFORMATIONS FOR THE SAME POLYPEPTIDE BOUND TO CHAPERONES DNAK AND GROEL [J].

LANDRY, SJ ;

JORDAN, R ;

MCMACKEN, R ;

GIERASCH, LM .

NATURE, 1992, 355 (6359) :455-457

← 1 2 3 4 5 →