学术探索
学术期刊
新闻热点
数据分析
智能评审

PUVA AND CANCER - A CASE-CONTROL STUDY

被引：24
作者：
LINDELOF, B
SIGURGEIRSSON, B
机构：
[1] Department of Dermatology, Karolinska Hospital, Stockholm
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1993年 / 129卷 / 01期
关键词：
D O I：
10.1111/j.1365-2133.1993.tb03308.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A detailed case-control study was carried out on 24 PUVA-treated patients with squamous cell cancer of the skin, and on an accurately matched control population of 96 PUVA-treated patients. Possible co-carcinogens, such as prior therapy with tar, ultraviolet-B, ionizing radiation, methotrexate and arsenic, were investigated. The only statistically significant association to emerge was that of prior therapy with methotrexate: relative risk 3.5; 95% confidence interval 1.2-9.9. Our data suggest that prior therapy with methotrexate might be a risk factor for skin cancer in PUVA-treated patients.
引用
收藏
页码：39 / 41
页数：3
相关论文
共 19 条
[1]  
ALBERT RE, 1976, CANCER SKIN BIOL DIA, V1, P111
[2]   IS METHOTREXATE THERAPY FOR PSORIASIS CARCINOGENIC - MODIFIED RETROSPECTIVE PROSPECTIVE ANALYSIS [J].
BAILIN, PL ;
TINDALL, JP ;
ROENIGK, HH ;
HOGAN, MD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 232 (04) :359-362
[3]   PUVA AND SKIN-CANCER - A HISTORICAL COHORT STUDY ON 492 PATIENTS [J].
CHUANG, TY ;
HEINRICH, LA ;
SCHULTZ, MD ;
REIZNER, GT ;
KUMM, RC ;
CRIPPS, DJ .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1992, 26 (02) :173-177
[4]  
FITZSIMONS CP, 1983, LANCET, V1, P235
[5]   LONG-TERM FOLLOW-UP OF SKIN-CANCER IN THE PUVA-48 COOPERATIVE STUDY [J].
FORMAN, AB ;
ROENIGK, HH ;
CARO, WA ;
MAGID, ML .
ARCHIVES OF DERMATOLOGY, 1989, 125 (04) :515-519
[6]  
GOTZ H, 1976, CANCER SKIN BIOL DIA, V1, P492
[7]   SKIN TUMORS IN THE EUROPEAN PUVA STUDY - 8-YEAR FOLLOW-UP OF 1,643 PATIENTS TREATED WITH PUVA FOR PSORIASIS [J].
HENSELER, T ;
CHRISTOPHERS, E ;
HONIGSMANN, H ;
WOLFF, K .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1987, 16 (01) :108-116
[8]  
LASSUS A, 1981, ACTA DERM-VENEREOL, V61, P141
[9]   INCIDENCE OF MALIGNANT SKIN TUMORS IN 14 140 PATIENTS AFTER GRENZ-RAY TREATMENT FOR BENIGN SKIN DISORDERS [J].
LINDELOF, B ;
EKLUND, G .
ARCHIVES OF DERMATOLOGY, 1986, 122 (12) :1391-1395
[10]   PUVA AND CANCER - A LARGE-SCALE EPIDEMIOLOGIC-STUDY [J].
LINDELOF, B ;
SIGURGEIRSSON, B ;
TEGNER, E ;
LARKO, O ;
JOHANNESSON, A ;
BERNE, B ;
CHRISTENSEN, OB ;
ANDERSSON, T ;
TORNGREN, M ;
MOLIN, L ;
NYLANDERLUNDQVIST, E ;
EMTESTAM, L .
LANCET, 1991, 338 (8759) :91-93
12