PUVA AND CANCER - A CASE-CONTROL STUDY

被引：24

作者：

LINDELOF, B

SIGURGEIRSSON, B

机构：

[1] Department of Dermatology, Karolinska Hospital, Stockholm

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1993年 / 129卷 / 01期

关键词：

D O I：

10.1111/j.1365-2133.1993.tb03308.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A detailed case-control study was carried out on 24 PUVA-treated patients with squamous cell cancer of the skin, and on an accurately matched control population of 96 PUVA-treated patients. Possible co-carcinogens, such as prior therapy with tar, ultraviolet-B, ionizing radiation, methotrexate and arsenic, were investigated. The only statistically significant association to emerge was that of prior therapy with methotrexate: relative risk 3.5; 95% confidence interval 1.2-9.9. Our data suggest that prior therapy with methotrexate might be a risk factor for skin cancer in PUVA-treated patients.

引用

页码：39 / 41

页数：3

共 19 条

[11]

LINDELOF B, 1992, ACTA DERM-VENER S, V169, P3

[12]

NYFORS A, 1980, METHOTREXATE THERAPY

[13]

SAUNDERSON KV, 1976, CANCER SKIN BIOL DIA, V1, P473

[14] CUTANEOUS SQUAMOUS-CELL CARCINOMA IN PATIENTS TREATED WITH PUVA [J].