Pleiotropic Effects of Antiarrhythmic Agents: Dronedarone in the Treatment of Atrial Fibrillation

被引：18

作者：

Heijman, Jordi ^{[1
]}

Heusch, Gerd ^{[2
]}

Dobrev, Dobromir ^{[1
]}

机构：

[1] Univ Duisburg Essen, Fac Med, Inst Pharmacol, Essen, Germany

[2] Univ Duisburg Essen, Fac Med, Inst Pathophysiol, Essen, Germany

来源：

CLINICAL MEDICINE INSIGHTS-CARDIOLOGY | 2013年 / 7卷

关键词：

antiarrhythmic drugs; atrial fibrillation; dronedarone; pleiotropic effects;

D O I：

10.4137/CMC.S8445

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus rhythm in patients with atrial fibrillation. Dronedarone is an amiodarone derivative developed to reduce the number of extracardiovascular side effects. Dronedarone has undergone extensive experimental and clinical testing during the last decade. On the aggregate, these studies have highlighted a complex set of pleiotropic actions that may contribute to dronedarone's antiarrhythmic effects. In this review, we summarize the clinical studies that have evaluated dronedarone and provide an overview of dronedarone's electrophysiological and nonelectrophysiological pleiotropic actions.

引用

页码：127 / 140

页数：14

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