SOLID-PHASE SYNTHESIS OF NONHYDROLYZABLE PHOSPHOTYROSYL PEPTIDE ANALOGS WITH N-ALPHA-FMOC-(O,O-DI-TERT-BUTYL)PHOSPHONO-PARA-METHYLPHENYLALANINE

被引：36

作者：

SHOELSON, SE

CHATTERJEE, S

CHAUDHURI, M

BURKE, TR

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT MED,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[3] NCI,MED CHEM LAB,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 43期

基金：

美国国家卫生研究院;

关键词：

PHOSPHOTYROSINE; TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; ENZYME INHIBITOR; PEPTIDE SYNTHESIS;

D O I：

10.1016/0040-4039(91)80753-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, protected derivative of phosphonomethylphenylalanine is used to synthesize nonhydrolyzable analogs of phosphotyrosyl peptides for use as inhibitors and affinity ligands of proteins that recognize phosphotyrosyl sequences.

引用

页码：6061 / 6064

页数：4

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