LIMITATIONS OF ENZYMATIC ACYLATION USING OXIME ESTERS - COSUBSTRATE INHIBITION AND THE REVERSIBILITY OF THE REACTION

被引：14

作者：

MISCHITZ, M ^{[1
]}

POSCHL, U ^{[1
]}

FABER, K ^{[1
]}

机构：

[1] GRAZ TECH UNIV,INST ORGAN CHEM,STREMAYRGASSE 16,A-8010 GRAZ,AUSTRIA

来源：

BIOTECHNOLOGY LETTERS | 1991年 / 13卷 / 09期

关键词：

D O I：

10.1007/BF01086321

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enzymatic resolution of (+/-)-endo-bicyclo[2.2.1]hept-5-en-2-ol (1a) catalysed by Candida cylindracea lipase using either acetoneoxime acetate (2a) or biacetyldioxime diacetate (3a) as acyl donor proceeds with moderate to good enantioselectivity (E = 13 and 22, resp.) although clear limitations of this method are observed: firstly, a severe depletion of the reaction rate at elevated cosubstrate (acyl donor) concentrations and secondly, the reversibility of the reaction.

引用

页码：653 / 656

页数：4

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