A POSITION EFFECT ON THE EXPRESSION OF A TRANSFER-RNA GENE MEDIATED BY THE SIR GENES IN SACCHAROMYCES-CEREVISIAE

被引：97

作者：

SCHNELL, R ^{[1
]}

RINE, J ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT BIOCHEM, BERKELEY, CA 94720 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1986年 / 6卷 / 02期

关键词：

D O I：

10.1128/MCB.6.2.494

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SIR genes of Saccharomyces cerevisiae are responsible for the position-dependent regulation of the a and .alpha. mating-type genes. Previous work by others has shown that the products of the SIR genes prevent the accumulation of stable transcripts of the a and .alpha. genes at HML and HMR. Results of this study establish that this regulation is a region-specific effect rather than a gene-specific effect since expression of a tRNA gene placed at HMR is repressed by the products of the SIR genes.

引用

页码：494 / 501

页数：8

共 44 条

[31]

PETERSON PA, 1976, GENETICS, V84, P469

[32] LABELING DEOXYRIBONUCLEIC-ACID TO HIGH SPECIFIC ACTIVITY INVITRO BY NICK TRANSLATION WITH DNA-POLYMERASE I [J].

RIGBY, PWJ ;

DIECKMANN, M ;

RHODES, C ;

BERG, P .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 113 (01) :237-251

[33]

RINE J, 1979, GENETICS, V93, P877

[34]

ROTHSTEIN RJ, 1983, METHOD ENZYMOL, V101, P202

[35] REPLACEMENT OF CHROMOSOME SEGMENTS WITH ALTERED DNA SEQUENCES CONSTRUCTED INVITRO [J].

SCHERER, S ;

DAVIS, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (10) :4951-4955

[36] TYROSINE SUBSTITUTIONS RESULTING FROM SUPPRESSION OF AMBER MUTANTS OF ISO-1-CYTOCHROME C IN YEAST [J].

SHERMAN, F ;

LIEBMAN, SW ;

STEWART, JW ;

JACKSON, M .

JOURNAL OF MOLECULAR BIOLOGY, 1973, 78 (01) :157-168

[37] TRANSCRIPTION AND REGULATORY SIGNALS AT THE MATING TYPE LOCUS IN YEAST [J].

SILICIANO, PG ;

TATCHELL, K .

CELL, 1984, 37 (03) :969-978

[38] NONSENSE SUPPRESSORS OF YEAST CAUSE OSMOTIC-SENSITIVE GROWTH [J].

SINGH, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (01) :305-309

[39] DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS [J].

SOUTHERN, EM .

JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) :503-+

[40] THE EFFECT OF CHROMOSOMAL POSITION ON THE EXPRESSION OF THE DROSOPHILA XANTHINE DEHYDROGENASE GENE [J].

SPRADLING, AC ;

RUBIN, GM .

CELL, 1983, 34 (01) :47-57

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