PREVENTION OF ALLERGIC SENSITIZATION TO BETA-LACTOGLOBULIN WITH CONJUGATES MADE OF BETA-LACTOGLOBULIN COUPLED TO ISOLOGOUS IMMUNOGLOBULIN-G

被引：8

作者：

FRITSCHE, R ^{[1
]}

BOREL, Y ^{[1
]}

机构：

[1] NESTEC LTD,NESTLE RES CTR,CH-1000 LAUSANNE 26,SWITZERLAND

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1994年 / 93卷 / 04期

关键词：

ALLERGY PREVENTION; BETA-LACTOGLOBULIN; ISOLOGOUS IGG; TOLEROGEN;

D O I：

10.1016/0091-6749(94)90258-5

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We have shown that, under certain conditions, a single dose of a conjugate of beta-lactoglobulin linked to isologous IgG suppresses specific antibody responses (IgE, IgG, and IgA) in rats immunized with beta-lactoglobulin. This suppression is allergen specific. If also appears to be effective when animals are first immunized and then tolerized. In addition, administration of the beta-lactoglobulin-IgG tolerogen abolishes mast cell mediator release. This has been shown both in vivo and with passively sensitized mast cells in vitro. We propose that the construction of a tolerogen made of whole protein allergen linked to IgG could provide a novel specific therapy for allergic reactions.

引用

页码：778 / 786

页数：9

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