PATHOGENESIS AND POTENTIAL STRATEGIES FOR PREVENTION AND TREATMENT OF SEPTIC SHOCK - AN UPDATE

被引：70

作者：

GLAUSER, MP

HEUMANN, D

BAUMGARTNER, JD

COHEN, J

机构：

[1] HAMMERSMITH HOSP, DEPT INFECT DIS, LONDON, ENGLAND

[2] HAMMERSMITH HOSP, DEPT BACTERIOL & MED, LONDON, ENGLAND

[3] ROYAL POSTGRAD MED SCH, LONDON, ENGLAND

来源：

CLINICAL INFECTIOUS DISEASES | 1994年 / 18卷

关键词：

D O I：

10.1093/clinids/18.Supplement_2.S205

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Septic shock is mediated by complex interactions of cells, cytokines, and humoral pathways. Clinical therapeutic strategies aimed at inhibiting selected pathways have been efficacious in subsets of patients. Experimental studies focusing on the activities of single cytokines have contributed to the understanding of the complex pathophysiology of septic shock. More precise delineation of the roles of each mechanism contributing to pathogenesis will permit the identification of subsets of patients who might benefit from particular therapeutic strategies and will guide the development of additional approaches to prevention and treatment.

引用

收藏

页码：S205 / S216

页数：12

相关论文

共 107 条

[71] LIPOPOLYSACCHARIDE ACTIVATION OF HUMAN ENDOTHELIAL AND EPITHELIAL-CELLS IS MEDIATED BY LIPOPOLYSACCHARIDE-BINDING PROTEIN AND SOLUBLE CD14 [J].

PUGIN, J ;

SCHURERMALY, CC ;

LETURCQ, D ;

MORIARTY, A ;

ULEVITCH, RJ ;

TOBIAS, PS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2744-2748

[72] A CONTROLLED TRIAL OF HA-1A IN A CANINE MODEL OF GRAM-NEGATIVE SEPTIC SHOCK [J].

QUEZADO, ZMN ;

NATANSON, C ;

ALLING, DW ;

BANKS, SM ;

KOEV, CA ;

ELIN, RJ ;

HOSSEINI, JM ;

BACHER, JD ;

DANNER, RL ;

HOFFMAN, WD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (17) :2221-2227

[73]

REINES HD, 1982, LANCET, V2, P174

[74] EFFICACY OF ANTIENDOTOXIN MONOCLONAL ANTIBODY-E5 ALONE OR IN COMBINATION WITH CIPROFLOXACIN IN NEUTROPENIC RATS WITH PSEUDOMONAS SEPSIS [J].

ROMULO, RLC ;

PALARDY, JE ;

OPAL, SM .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (01) :126-130

[75]

Rothstein J L, 1992, Immunol Ser, V56, P453

[76] SYNERGY BETWEEN TUMOR NECROSIS FACTOR AND BACTERIAL PRODUCTS CAUSES HEMORRHAGIC NECROSIS AND LETHAL SHOCK IN NORMAL MICE [J].

ROTHSTEIN, JL ;

SCHREIBER, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (02) :607-611

[77] THE ROLE OF CYTOKINES IN THE GENERATION OF INFLAMMATION AND TISSUE-DAMAGE IN EXPERIMENTAL GRAM-POSITIVE MENINGITIS [J].

SAUKKONEN, K ;

SANDE, S ;

CIOFFE, C ;

WOLPE, S ;

SHERRY, B ;

CERAMI, A ;

TUOMANEN, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) :439-448

[78] STRUCTURE AND FUNCTION OF LIPOPOLYSACCHARIDE BINDING-PROTEIN [J].

SCHUMANN, RR ;

LEONG, SR ;

FLAGGS, GW ;

GRAY, PW ;

WRIGHT, SD ;

MATHISON, JC ;

TOBIAS, PS ;

ULEVITCH, RJ .

SCIENCE, 1990, 249 (4975) :1429-1431

[79] ENDOGENOUSLY SYNTHESIZED NITRIC-OXIDE PREVENTS ENDOTOXIN-INDUCED GLOMERULAR THROMBOSIS [J].

SHULTZ, PJ ;

RAIJ, L .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (05) :1718-1725

[80] ROLE OF PEPTIDOGLYCAN FROM STAPHYLOCOCCUS-AUREUS IN LEUKOPENIA, THROMBOCYTOPENIA, AND COMPLEMENT ACTIVATION ASSOCIATED WITH BACTEREMIA [J].

SPIKA, JS ;

PETERSON, PK ;

WILKINSON, BJ ;

HAMMERSCHMIDT, DE ;

VERBRUGH, HA ;

VERHOEF, J ;

QUIE, PG .

JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (02) :227-234

← 2 3 4 5 6 7 8 9 10 11 →