BONE METASTASIS FROM COLORECTAL-CANCER IN AUTOPSY CASES

被引:79
作者
KATOH, M [1 ]
UNAKAMI, M [1 ]
HARA, M [1 ]
FUKUCHI, S [1 ]
机构
[1] TORANOMON GEN HOSP,DEPT GASTROENTEROL,MINATO KU,TOKYO 105,JAPAN
关键词
COLORECTAL CANCER; BONE METASTASIS; HEMATOGENOUS METASTASIS;
D O I
10.1007/BF02367787
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The incidence of bone metastasis from colorectal cancer is reported to be 10.7% in autopsy cases. However, the characteristics of the primary cancers, as well as the patterns of bone metastasis, remain unclear. We analyzed the clinical and autopsy records of 118 patients with primary colorectal cancer treated either surgically or conservatively and eventually autopsied between 1970 and 1987 at Toranomon Hospital in Tokyo. Bone metastasis was detected in 23.7% (28/118). The average age of patients with bone metastasis was lower than that in patients without bone metastasis (P < 0.02). Cancers to the rectum and cecum were accompanied by bone metastasis more frequently than cancers of other portions of the colon. Signet-ring cell carcinoma showed a high incidence of bone metastasis (P = 0.041). Bone metastasis from associated with liver or lung (P < 0.0001). These results indicated that bone metastasis from colorectal cancer is not as infrequent as previously described.
引用
收藏
页码:615 / 618
页数:4
相关论文
共 17 条
[11]  
Katoh M., Terada M., Oncogenes and tumor suppressor genes, Gastric cancer, pp. 196-208, (1993)
[12]  
Vogelstein B., Fearon E.R., Hamilton S.R., Et al., Genetic alterations during colorectal tumor development, N Engl J Med, 319, pp. 525-532, (1988)
[13]  
Fearon E.R., Vogelstein B., A genetic model for colorectal tumorgenesis, Cell, 61, pp. 759-767, (1990)
[14]  
Delattre O., Olschwang S., Law D.J., Et al., Multiple genetic alterations in distal and proximal colorectal cancer, Lancet, 2, pp. 353-355, (1989)
[15]  
Batson O.V., The vertebral systems of veins as a means of cancer dissemination, Prog Clin Cancer, 3, pp. 1-18, (1967)
[16]  
Fidler I.J., Special lecture: Critical factors in the biology of human cancer metastasis: Twenty-eigh the GHA Clowes memorial lecture, Cancer Res, 50, pp. 6130-6138, (1990)
[17]  
Radinsky R., Paracrine growth regulation of human colon carcinoma organ-specific metastasis, Cancer Metastasis Rev, 12, pp. 345-361, (1993)